Virtual Method Tables
R5AC is ensuring that VMTP's are pointing within expected bounds, and that read-only VMT related data has not been tampered with.
Here is an example of how this detection might look like.
char __fastcall sub_1DCDD1()
{
FilesystemInterface = (__int64 *)R5::VTP_GetFilesystemInterface();
*((_QWORD *)v2 + 16) = FilesystemInterface;
gpFileSystemInterface[0] = FilesystemInterface;
return 1;
}